Occupational acrylonitrile exposure and lung cancer: a meta-analysis.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
; 24(2): 257-84, 2006.
Article
em En
| MEDLINE
| ID: mdl-17114112
ABSTRACT
The present work summarizes the currently available published studies on lung cancer and occupational acrylonitrile exposure. Meta-analytic methods were used to estimate the overall risk. To adjust for the healthy worker effect, rate ratio estimates based on regression analyses and ratios of standard mortality ratios were aggregated. Overall effect estimates were 0.95 (95% CI 0.86 to 1.06) and 1.25 (95% CI 1.10 to 1.43) before and after adjustment for the healthy worker effect, respectively. Therefore, a 25% increase in lung cancer risk attributable to occupational acrylonitrile exposure is suggested. Possible contribution of smoking confounding the increased risk cannot be fully excluded.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acrilonitrila
/
Carcinógenos
/
Exposição Ocupacional
/
Neoplasias Pulmonares
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
Assunto da revista:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Suíça