Transporter assays using solid supported membranes: a novel screening platform for drug discovery.
Assay Drug Dev Technol
; 4(5): 575-82, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-17115928
ABSTRACT
Transporters are important targets in drug discovery. However, high throughput-capable assays for this class of membrane proteins are still missing. Here we present a novel drug discovery platform technology based on solid supported membranes. The functional principles of the technology are described, and a sample selection of transporter assays is discussed the H(+)-dependent peptide transporter PepT1, the gastric proton pump, and the Na(+)/Ca(2+) exchanger. This technology promises to have an important impact on the drug discovery process.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Bioensaio
/
Técnicas Biossensoriais
/
Desenho de Fármacos
/
Técnicas Analíticas Microfluídicas
/
Eletroquímica
/
Membranas Artificiais
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
/
Screening_studies
Idioma:
En
Revista:
Assay Drug Dev Technol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Alemanha