[Antigenic diversity of asexual schizont antigen GP195 of Plasmodium falciparum isolates from China].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
; 9(2): 110-3, 1991.
Article
em Zh
| MEDLINE
| ID: mdl-1714800
ABSTRACT
The antigenic diversity of asexual merozoite surface antigen precursor gp195 among 6 isolates of Plasmodium falciparum from Hainan and Jiangsu provinces of China was investigated with a panel of murine anti-gp195 McAbs by indirect immunofluorescence assay and Western blotting. The results show that all isolates express certain strain-common epitopes of gp195, and at the same time express or lack some strain-specific epitopes. The 6 isolates can be divided into two major gp195 serotypes according to the reactivity patterns with the panel of anti-gp195 McAbs. Remarkable molecular weight difference in gp195 was found among 4 isolates of P. falciparum in which the Jiangsu isolate possesses a large size of gp195 (210kDa) than the other 3 Hainan isolates (less than or equal to 200kDa). The polymorphism of gp195 and it's impact on the development of antimalarial vaccine is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Epitopos
/
Antígenos de Protozoários
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
Assunto da revista:
PARASITOLOGIA
Ano de publicação:
1991
Tipo de documento:
Article