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Effect of angiotensin converting enzyme inhibitors on 1.25-(OH)2 D levels of hypertensive patients. Relationship with ACE polymorphisms.
Pérez-Castrillón, J L; Justo, I; Sanz, A; De Luis, D; Dueñas, A.
Afiliação
  • Pérez-Castrillón JL; Departamento de Medicina Interna, Hospital Universitario Río Hortega, Facultad de Medicina de Valladolid, Valladolid, Spain. castrv@terra.es
Horm Metab Res ; 38(12): 812-6, 2006 Dec.
Article em En | MEDLINE | ID: mdl-17163356
BACKGROUND: The effect of angiotensin converting enzyme inhibitors (ACEIs) on 1.25-dihydroxyvitamin D [1.25-(OH)2D] levels has not been studied. The purpose of this study is to assess the relationship between 1.25-dihydroxyvitamin D levels and I/D angiotensin-converting enzyme polymorphism (ACE) in hypertensive patients. MATERIALS AND METHODS: The study included 60 individuals (31 females and 29 males) with systolic and/or diastolic hypertension. The 25-hydroxyvitamin D levels were measured by HPLC and the 1.25-(OH)2 D was determined by RIA. ACE polymorphism was analyzed by Polymerase Chain Reaction (PCR) using a modification of the original method described by Rigat. RESULTS: Treatment with ACEIs produced an increase in total calcium (p=0.003) and a decrease in the 1.25-(OH)2 D (p=0.0001). No relationship between final calcium and 1.25-(OH)2 D (r=-0.171, p=0.198) was observed. When the effects of enalapril and quinapril were analyzed separately, the results were similar. When the patients were divided according to genotype, the decrease in 1.25-(OH)2 D was observed only in patients with D allele, genotype Ins/Del (69+/-23 vs. 48+/-19, p=0.021 ) and in those of genotype Del/Del (64+/-19 vs. 17, p=0.004). CONCLUSION: The ACE inhibitors in combination with the presence of the DD genotype decrease the level of 1.25-(OH)2 D. There was no difference between enalapril and quinapril treated groups.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Calcitriol / Inibidores da Enzima Conversora de Angiotensina / Peptidil Dipeptidase A / Hipertensão Tipo de estudo: Clinical_trials Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Horm Metab Res Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Espanha País de publicação: Alemanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Calcitriol / Inibidores da Enzima Conversora de Angiotensina / Peptidil Dipeptidase A / Hipertensão Tipo de estudo: Clinical_trials Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Horm Metab Res Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Espanha País de publicação: Alemanha