Histopathologic abnormalities of the lymphoreticular tissues in organic cation transporter 2 deficiency: evidence for impaired B cell maturation.
J Pediatr
; 150(1): 109-111.e2, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17188629
ABSTRACT
Immunohistology of lymphoreticular tissues of a fatal case of organic cation transporter 2 deficiency revealed inhibited proliferation with increased apoptosis in the germinal centers, resulting in "burned out" follicles. This is indicative of impaired antigen driven B cell affinity maturation. Defective humoral immune response might explain the recurrent infections in untreated organic cation transporter 2 deficiency.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Respiratórias
/
Linfócitos B
/
Proteínas de Transporte de Cátions Orgânicos
/
Crescimento Celular
/
Tecido Linfoide
Limite:
Child, preschool
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Hungria