[Serum acute phase proteins for determining disease activity of ulcerative colitis and Crohn disease]. / Akutphasenproteine im Serum zur Aktivitätsbeurteilung von Colitis ulcerosa und Morbus Crohn.
Acta Med Austriaca
; 18(4): 100-5, 1991.
Article
em De
| MEDLINE
| ID: mdl-1722373
ABSTRACT
We studied the activity assessment of ulcerative colitis and Crohn's disease by 5 acute phase reactants C-reactive protein (CRP), alpha 1-acid glycoprotein, alpha 1 antitrypsin, haptoglobin and fibrinogen. From a large register of patients with inflammatory bowel disease (IBD) we chose randomly 91 patients 61 with ulcerative colitis and 30 with Crohn's disease. As a reference point in the disease activity assessment we used standard clinical indices. Statistical analysis was performed by non-parametric methods:
the Kruskal-Wallis and Fisher's exact test. The disease activity assessment in patients with ulcerative colitis by the index according to Powell-Tuck indicated that the patients with active disease (N = 19) had significantly higher levels of all acute phase proteins mentioned above except fibrinogen (alpha less than 0.05 to 0.001) than patients in remission (N = 42). Analysis of the same data by Fisher's exact test indicated that there had been a probability for all the proteins measured to be higher than the normal values, particullary CRP (p less than 10(-8) and the other somewhat less. In patients with Crohn's disease, the disease activity assessment was performed by 2 indices. According to "The Crohn's Disease Activity Index" (CDAI), only alpha-1 acid glycoprotein and haptoglobin (alpha less than 0.05) were higher in patients with active disease (N = 4) than in patients with remission (N = 26).(ABSTRACT TRUNCATED AT 250 WORDS)
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Fase Aguda
/
Colite Ulcerativa
/
Doença de Crohn
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
De
Revista:
Acta Med Austriaca
Ano de publicação:
1991
Tipo de documento:
Article