Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype.
J Neural Transm (Vienna)
; 114(5): 635-9, 2007.
Article
em En
| MEDLINE
| ID: mdl-17225932
ABSTRACT
BACKGROUND:
Homozygote carriers of two long (L) alleles of the serotonin transporter (5-HTT) regulatory region displayed in vitro a twofold increase in 5-HTT expression compared with carriers of one or two short (S) alleles. However, in vivo imaging studies yielded contradictory results. Recently, an A > G exchange leading to differential transcriptional activation of 5-HTT mRNA in lymphobalstoid cell lines was discovered in the 5-HTT regulatory region. In vitro and in vivo evidence suggests that [(11)C]DASB, a new 5-HTT ligand offers some advantages over the ligands used in previous studies in measuring 5-HTT density independent of synaptic levels of serotonin.METHOD:
We assessed 5-HTT binding potential (BP (2)) in the midbrain of 19 healthy subjects with positron emission tomography and [(11)C]DASB. Accounting for the hypothesized functional similarity of L (G) and S in driving 5-HTT transcription, we assessed whether L (A) L (A) homozygotes display increased midbrain BP (2) compared with carriers of at least one S allele.RESULTS:
BP (2) in the midbrain was significantly increased in L (A) L (A) homozygotes compared with carriers of at least one S allele. Interestingly, the genotype effect on the midbrain was significantly different from that on the thalamus and the amygdala where no group differences were detected.CONCLUSIONS:
This in vivo study provides further evidence that subjects homozygous for the L (A) allele display increased expression of 5-HTT in the midbrain, the origin of central serotonergic projections.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mesencéfalo
/
Serotonina
/
Proteínas da Membrana Plasmática de Transporte de Serotonina
Limite:
Adult
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Neural Transm (Vienna)
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Alemanha