Effects of ryo-kan-kyomi-sin-ge-nin-to extract on degranulation of and histamine release from rat mast cells.
Am J Chin Med
; 19(3-4): 243-9, 1991.
Article
em En
| MEDLINE
| ID: mdl-1722640
ABSTRACT
The effects of Ryo-kan-kyomi-sin-ge-nin-to (RKSG)) extract, a medicinal agent traditionally used in China and Japan for treatment of asthma, on the degranulation of and histamine release from rat mast cells were studied. At a concentration of 5 mg/ml RKSG, degranulation of mast cells stimulated either by antigen (DNP-Ascaris) or compound 48/80 was markedly suppressed. At a concentration of 1-5 mg/ml RKSG, histamine release from mast cells due to application of either antigen or compound 48/80 was inhibited in a dose-dependent fashion. These results suggest that RKSG may be useful for the treatment of type I allergy-related diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Asma
/
Medicamentos de Ervas Chinesas
/
Degranulação Celular
/
Glycyrrhiza
/
Liberação de Histamina
/
Mastócitos
Limite:
Animals
Idioma:
En
Revista:
Am J Chin Med
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Japão