Mosaic structure of foot-and-mouth disease virus genomes.
J Gen Virol
; 88(Pt 2): 487-492, 2007 Feb.
Article
em En
| MEDLINE
| ID: mdl-17251567
ABSTRACT
The results of a simple pairwise-scanning analysis designed to identify inter-serotype recombination fragments, applied to genome data from 156 isolates of Foot-and-mouth disease virus (FMDV) representing all seven serotypes, are reported. Large numbers of candidate recombinant fragments were identified from all parts of the FMDV genome, with the exception of the capsid genes, within which such fragments are infrequent. As expected, intertypic fragment exchange is most common between geographically sympatric FMDV serotypes. After accounting for the likelihood of intertypic convergence in highly conserved parts of the FMDV genome, it is concluded that intertypic recombination is probably widespread throughout the non-structural genes, but that recombination over the 2B/C and 3B/C gene boundaries appears to be less frequent than expected, given the large numbers of recombinant gene fragments arising in these genes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recombinação Genética
/
Proteínas Virais
/
DNA Viral
/
Genoma Viral
/
Vírus da Febre Aftosa
Limite:
Animals
Idioma:
En
Revista:
J Gen Virol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido