Clinical indices of familial depression in the Swedish Twin Registry.
Acta Psychiatr Scand
; 115(3): 214-20, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17302621
ABSTRACT
OBJECTIVE:
Although familial factors certainly contribute to the etiology of major depression (MD), further information is needed about which clinical features of depressive illness index the familial vulnerability in MD.METHOD:
Lifetime MD and associated clinical features were assessed at personal interview in 27 230 individual twins, including 4080 onsets of MD, from the Swedish National Twin Registry. Analyses were conducted using Cox proportional hazards models.RESULTS:
Three clinical variables in a depressed twin predicted the hazard ratio for MD in the cotwin. In the order of the strength of the association, these were number of endorsed A criteria, age at onset, and number of episodes.CONCLUSION:
Certain clinical features of MD are significant, albeit modest, indices of the familial vulnerability to MD. Individuals with a high familial/genetic risk for MD tend to have an early age at onset, meet most of the symptomatic DSM criteria and suffer recurrences.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gêmeos
/
Sistema de Registros
/
Transtorno Depressivo Maior
Tipo de estudo:
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos