Tumor induced by Moloney sarcoma virus causes periosteal osteogenesis engaging osteopontin, fibronectin, stromelysin-1 and tenascin.
Neoplasma
; 54(2): 173-9, 2007.
Article
em En
| MEDLINE
| ID: mdl-17319793
ABSTRACT
Excessive bone formation occurring in such conditions as paravertebral ligamentous ossification, hallux osteophytes or some neoplastic tumors, presents a significant problem, both epidemiological and clinical. Since pathogenesis of this disorder is still unclear, we studied its mechanism in experimental model utilizing inducible orthotopic osteogenesis. Periosteal bone apposition stimulated by Moloney sarcoma is characterized by unusually high volume of new bone tissue appearing subperiosteally in the bone adjacent to the tumor. Genes engaged in this growth have not been characterized so far. Here we show the results of mRNA Representation Difference Analysis in Moloney sarcoma, which reveal high expression of four genes coding extracellular matrix proteins osteopontin, fibronectin, stromelysin-1 and tenascin. These findings suggest that the uncommon dynamics of the Moloney sarcoma-induced osteogenesis depends on high expression of these extracellular matrix proteins.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteogênese
/
Periósteo
/
Sarcoma Experimental
/
Fibronectinas
/
Tenascina
/
Metaloproteinase 3 da Matriz
/
Osteopontina
/
Vírus do Sarcoma Murino de Moloney
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neoplasma
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Polônia
País de publicação:
ESLOVAQUIA
/
ESLOVÁQUIA
/
SK
/
SLOVAKIA