Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin.
Clin Pharmacol Ther
; 81(5): 650-3, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17329991
ABSTRACT
Statins are generally well tolerated, but can cause myopathy and have been associated with mitochondrial abnormalities. The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published clinical trial of high-dose simvastatin or atorvastatin versus placebo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Mitocondrial
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Sinvastatina
/
Mitocôndrias Musculares
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Finlândia
