[Carminerin contributes to chondrocyte calcification during pathological endochondral ossification].
Clin Calcium
; 17(3): 373-9, 2007 Mar.
Article
em Ja
| MEDLINE
| ID: mdl-17339741
ABSTRACT
Endochondral ossification is an essential process not only for physiological skeletal development and growth, but also for pathological disorders such as osteophyte formation in osteoarthritic joints and ectopic ossification with ageing. We recently identified a novel cartilage-specific molecule carminerin. Although the carminerin-deficient mice developed and grew normally, pathological endochondral ossification were suppressed. We conclude that carminerin contributes to chondrocyte calcification during pathological endochondral ossification without affecting physiological skeletal conditions, suggesting that this molecule could be a therapeutic target for these disorders.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cistatinas
/
Ossificação Heterotópica
/
Condrócitos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Ja
Revista:
Clin Calcium
Assunto da revista:
METABOLISMO
Ano de publicação:
2007
Tipo de documento:
Article