[Detection of free light chains--a new method of diagnostics of haematological diseases]. / Detekce volných lehkých retezcu ("free light chains")--nová metoda diagnostiky hematologickych onemocneí.
Cas Lek Cesk
; 146(2): 159-62, 2007.
Article
em Cs
| MEDLINE
| ID: mdl-17373113
ABSTRACT
BACKGROUND:
To diagnose monoclonal gamopathy, one of the most frequent haematological diseases, we use immunochemical assays, which are based on the detection of paraprotein in serum and/or urine. METHODS ANDRESULTS:
The most common laboratory assays we use are SPE (serum protein electrophoresis) and IFE (immunofixation electrophoresis). New method represents the detection of free light chain (FLC) in serum. In our study we compared those three methods (SPE, IFE and FLC) from the point of sensitivity of paraprotein detection. For FLC detection was used Freelite system analyzer (Immunotech Beckman Coulter). We examined 51 patients with diagnosis of multiple myeloma, nonHodgkin's lymphoma, primary amyloidosis and monoclonal gammopathy of undetermined significance.CONCLUSIONS:
Detection of FLC is a valuable method which sometimes could specify diagnosis of MG and make the treatment more accurate.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paraproteinemias
/
Cadeias Leves de Imunoglobulina
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Cs
Revista:
Cas Lek Cesk
Ano de publicação:
2007
Tipo de documento:
Article