[Perspectives in the treatment of subarachnoid-hemorrhage-induced cerebral vasospasm]. / Perspectivas en el tratamiento del vasospasmo cerebral inducido por hemorragiasubaracnoidea.
Neurocirugia (Astur)
; 18(1): 16-27, 2007 Feb.
Article
em Es
| MEDLINE
| ID: mdl-17393042
ABSTRACT
Cerebral vasospasm is still the most important cause of death and disability after rupture of intracranial aneurysms. The therapeutic strategies in the treatment of subarachnoid hemorrhage induced vasospasm vasospasm include four groups 1) prevention of vasospasm; 2) reversion of vasospasm; 3) improvement of cerebral perfusion; and 4) neuroprotection and rescue therapies. Recent experimental studies allowed the design of phase II clinical studies which demonstrated positive results with medications and compounds such as statins (simvastatin and pravastatin) and endothelin-1 receptor antagonists (clasozentan). Moreover, experimental and clinical evidences showed the advantages of early cerebrospinal fluid drainage, intrathecal administration of NO-donors, effects of Ca2+ protein kinase inhibitor (Fasudil) and catecholamines on the cerebral vessels. This review article summarizes the stage of investigation of these medications and therapeutic strategies which will be relevant in the treatment of cerebral vasospasm.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemorragia Subaracnóidea
/
Vasoespasmo Intracraniano
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
Es
Revista:
Neurocirugia (Astur)
Assunto da revista:
NEUROCIRURGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
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