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Effect of long-term mental and pain stress on the dynamics of H4 histone acetylation in hippocampal neurons of rats with different levels of nervous system excitability.
Sokolova, N E; Shiryaeva, N V; Dyuzhikova, N A; Savenko, Yu N; Vaido, A I.
Afiliação
  • Sokolova NE; Laboratory of Genetics of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. shiryaeva@kolt.infran.ru.
Bull Exp Biol Med ; 142(3): 341-3, 2006 Sep.
Article em En, Ru | MEDLINE | ID: mdl-17426844
Priority data on specific effect of long-term mental and pain stress on the dynamics of H4 histone acetylation in the pyramidal neuron nuclei of the hippocampal CA3 field in rats selected by the nervous system excitability were obtained using a comparative genetic method. The congruency of long-term post-stress modification of H4 histone acetylation in neurons of rats with high threshold excitability and behavioral changes intrinsic of these rats suggest that increased acetylation of H4 histone together with changes in heterochromatin conformation play a triggering role in long-term modifications of genome expression underlying the pathogenesis of posttraumatic stress disorders and other psychogenias.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Estresse Psicológico / Histonas / Hipocampo / Neurônios Limite: Animals Idioma: En / Ru Revista: Bull Exp Biol Med Ano de publicação: 2006 Tipo de documento: Article País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Estresse Psicológico / Histonas / Hipocampo / Neurônios Limite: Animals Idioma: En / Ru Revista: Bull Exp Biol Med Ano de publicação: 2006 Tipo de documento: Article País de publicação: Estados Unidos