Downstream intracellular effectors of epidermal growth factor receptor as targets for anticancer therapy.
Expert Opin Ther Targets
; 11(6): 771-82, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17504015
ABSTRACT
In recent years, the knowledge about mutations in components of the intracellular signal transduction pathway has greatly improved. Pivotal target molecules, such as Ras, PI3K, mammalian target of rapamycin (mTOR) and PKC, form an important biochemical network, which, when mutated, drives cell growth in an unlimited manner. Cancer cells have been shown to be able to harness different growth factor signalling pathways. Protein kinase inhibitors, targeted to the above pathways, have demonstrated activity against several solid tumours and are generally better tolerated than standard cytotoxic agents. The future challenge will be to find the most clever way to use combinations of these novel compounds.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Sistemas de Liberação de Medicamentos
/
Receptores ErbB
/
Inibidores do Crescimento
/
Líquido Intracelular
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Opin Ther Targets
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália