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Development of self-indicating resin.
Ichihara, Osamu; Sampson, David; Whittaker, Mark; Bradley, Mark; Cho, Jin Ku.
Afiliação
  • Ichihara O; Evotec UK Ltd., 111 Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK. osamu.ichihara@evotec.com
Comb Chem High Throughput Screen ; 10(4): 261-7, 2007 May.
Article em En | MEDLINE | ID: mdl-17506709
Previously, we have reported the development and application of self-indicating resins (SIR), materials which can indicate presence or absence of amines in the reaction solution by the conspicuous color change of a phenolsulfophthalein type dye immobilized on resin beads [2a]. Although the functionality necessary for attaching the dye to the resins could be readily introduced by the Suzuki-Miyaura coupling during the synthesis of the SIR 1, this approach was only applicable to the dyes containing suitable functionality for the cross-coupling reaction. In this article we describe a new approach of immobilizing the indicating dyes onto the resin support. The dyes suitable for loading onto aminomethyl polystyrene (PS) resin were prepared by Friedel-Crafts reaction of 2-sulfoterephthalic anhydride with a wide range of phenols. Using this new route, the SIR 6c was readily prepared in >100g quantities. Use of the SIR 6c in the synthesis of a 144 member urea library was demonstrated and the SIR successfully indicated the endpoint of the reaction between amines and isocyanates.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliestirenos / Resinas Sintéticas Idioma: En Revista: Comb Chem High Throughput Screen Assunto da revista: BIOLOGIA MOLECULAR / QUIMICA Ano de publicação: 2007 Tipo de documento: Article País de publicação: Emirados Árabes Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliestirenos / Resinas Sintéticas Idioma: En Revista: Comb Chem High Throughput Screen Assunto da revista: BIOLOGIA MOLECULAR / QUIMICA Ano de publicação: 2007 Tipo de documento: Article País de publicação: Emirados Árabes Unidos