Triterpenoid saponins, new metalloprotease snake venom inhibitors isolated from Pentaclethra macroloba.
Toxicon
; 50(2): 283-91, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17517426
ABSTRACT
We report here the antiproteolytic and antihemorrhagic properties of triterpenoid saponin inhibitors, named macrolobin-A and B, from Pentaclethra macroloba, against Bothrops snake venoms. The inhibitors were able to neutralize the hemorrhagic, fibrin(ogen)olytic, and proteolytic activities of class P-I and P-III metalloproteases isolated from B. neuwiedi and B. jararacussu venoms. Clotting and fibrinogenolytic activities induced by snake venoms and isolated thrombin-like enzymes were partially inhibited. Furthermore, the potential use of these inhibitors to complement antivenom therapy as an alternative treatment and/or used as molecular models for development of new therapeutical agents in the treatment of snake bite envenomations needs to be evaluated in future studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas
/
Saponinas
/
Venenos de Serpentes
/
Triterpenos
/
Inibidores de Serina Proteinase
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Toxicon
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Brasil