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Controllable release of salmon-calcitonin in injectable calcium phosphate cement modified by chitosan oligosaccharide and collagen polypeptide.
Li, D X; Fan, H S; Zhu, X D; Tan, Y F; Xiao, W Q; Lu, J; Xiao, Y M; Chen, J Y; Zhang, X D.
Afiliação
  • Li DX; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
J Mater Sci Mater Med ; 18(11): 2225-31, 2007 Nov.
Article em En | MEDLINE | ID: mdl-17619977
The aim of this research is to study the effect of the controlled releasing character of the salmon calcitonin (S-CT) loaded injectable calcium phosphate cement (CPC) modified by adding organic phase, chitosan oligosaccharide (CO) and collagen polypeptide (CP). The uniform design was used to determine the basic formulation with suitable injectable time for clinical application, and then the changes of the physical characters, the controlled releasing character of the modified CPC along with the ratio of the organic phase were also evaluated in vitro. The surface morphous of the modified CPC been implanted in the abdominal cavity or soaked into the serum of rat was also observed by scanning electron microscope (SEM). The result shows that a suitable formulation of modified CPC could be got, and the injectable time is 12 min, the compressive strength is 12 MPa, and the final setting time is 40 min. Comparing with the CPC without organic phase, the releasing rate of S-CT would increase along with the increase of the organic phase after 7th day. Therefore, a novel S-CT loaded bioactive injectable CPC for treating osteoporosis induced bone defect was obtained, and the release of the containing S-CT was controlled easily through adjusting the ratio of CO and CP.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Peptídeos / Fosfatos de Cálcio / Calcitonina / Portadores de Fármacos / Colágeno / Quitosana Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Revista: J Mater Sci Mater Med Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Peptídeos / Fosfatos de Cálcio / Calcitonina / Portadores de Fármacos / Colágeno / Quitosana Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Revista: J Mater Sci Mater Med Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos