Current status of allogeneic stem cell transplantation for treatment of hematologic malignancies.
Clin Pharmacol Ther
; 82(3): 325-9, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17637786
ABSTRACT
Bone marrow transplantation has evolved significantly over the past 40 years. The initial rationale of using donor bone marrow to guarantee a supply of hematopoietic stem cells uncontaminated by tumor remains a relevant principle today. However, the donor hematopoietic cells also exert an important immunological, therapeutic effect in the recipient. This synopsis will consider the balance of conditioning therapy intensity and immunological effect of allogeneic stem cell transplantation, informing the positioning of these approaches in current treatment algorithms.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hematológicas
/
Transplante de Células-Tronco
Limite:
Humans
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido