[What can be expected from the GLP-1 agonists and DPP-4 inhibitors in the treatment of type 2 diabetes?]. / Traitement du diabète de type 2: qu'attendre des analogues du GLP-1 et inhibiteurs de la DPP-4?
Rev Med Suisse
; 3(114): 1449-50, 1453-5, 2007 Jun 06.
Article
em Fr
| MEDLINE
| ID: mdl-17639666
ABSTRACT
The GLP-1 agonists and DPP-4 inhibitors are two novel drug classes in the treatment of type 2 diabetes. They increase insulin secretion and inhibit glucagon secretion without risk of hypoglycaemia. A decrease of glycated haemoglobin of about 1% can be expected with their use as monotherapy and as add-on therapy to the usual oral antidiabetics. In addition, GLP-1 agonists induce weight reduction at the price of gastro-intestinal side-effects and the need for subcutaneous administration. DPP-4 inhibitors can be taken orally, are well-tolerated, but weight-neutral. In the absence of relevant clinical studies, their long-term efficacy is currently unknown, as well as the clinical impact of other promising effects like beta-cell preservation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
/
Hipoglicemiantes
Limite:
Humans
Idioma:
Fr
Revista:
Rev Med Suisse
Assunto da revista:
MEDICINA
Ano de publicação:
2007
Tipo de documento:
Article