Association between Parkinson's disease and glucocerebrosidase mutations in Brazil.
Parkinsonism Relat Disord
; 14(1): 58-62, 2008.
Article
em En
| MEDLINE
| ID: mdl-17703984
ABSTRACT
OBJECTIVE:
To evaluate the association between parkinsonism and mutations in the glucocerebrosidase gene (GBA) in Brazilian patients.METHODS:
We searched for three GBA common mutations (N370S, L444P and G377S) in 65 Brazilian patients affected by PD with disease onset before the age of 55 and compared the results to 267 age- and sex-matched controls.RESULTS:
GBA mutations were detected at a significantly higher frequency among Parkinson's disease patients (2/65=3%), when compared to the control group (0/267) P=0.0379.CONCLUSION:
These results provide further evidence for GBA mutations being a possible hereditary risk factor for PD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Predisposição Genética para Doença
/
Glucosilceramidase
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Parkinsonism Relat Disord
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil