Immune responses of the ovine lymph node to Chlamydia psittaci. A cellular study of popliteal efferent lymph.
J Comp Pathol
; 105(2): 191-202, 1991 Aug.
Article
em En
| MEDLINE
| ID: mdl-1779041
ABSTRACT
The popliteal efferent lymphatics were cannulated in sheep of two categories, seronegative or immune to Chlamydia psittaci. Following subcutaneous injection of live C. psittaci or control material into the draining area of the popliteal node, sequential samples of efferent lymph were collected and analysed. Both categories of sheep responded to C. psittaci with increased outputs of lymphocytes and blast cells. Numbers of blast cells rose both absolutely and as a proportion of the total. Plasmablasts increased in number only in seronegative sheep. Outputs of total T cells (CD5+), helper T cells (CD4+), cytotoxic/suppressor T cells (CD8+) and non-helper, non-suppressor T cells (T19) were maximal 4 and 7 days after challenge in immune and seronegative sheep, respectively. Proportionally, CD4+ T cells declined, CD8+ T cells increased and T19 cells were unaltered with time after infection. Chlamydial antigens could not be demonstrated in the cells of efferent lymph by an immunoperoxidase method. The results of this preliminary study show that both T and B cell responses are involved in immunity to C. psittaci.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Psitacose
/
Ovinos
/
Chlamydophila psittaci
/
Linfonodos
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Comp Pathol
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Reino Unido
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM