Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms.
J Pharm Sci
; 97(7): 2395-404, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-17828756
ABSTRACT
Biodegradable poly(lactide-co-glycolide) (PLGA) polymers have been studied extensively for the controlled release of peptide and protein drugs. In addition to polymer biodegradation, chemical degradation of the incorporated peptide/protein has also been reported in PLGA devices, and the role of the polymer in promoting these reactions has been debated. This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms. Reported methods for stabilizing peptides and proteins in PLGA devices are also discussed.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Portadores de Fármacos
/
Preparações Farmacêuticas
/
Proteínas
/
Glicolatos
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos