Screening for Chlamydia trachomatis infection in women and aspects of the laboratory diagnostics.

ABSTRACT

PIP: 933 women who attended a gynecologic clinic for the treatment of various symptoms, to receive contraceptives, or to undergo abortion were screened for genital Chlamydia trachomatis infection. A total of 95 *10.2%) women were found to be infected. Of the women under age 25, 13.4% were infected, as compared with 4.9% over the age of 25. Women with genital infection symptoms were not overrepresented in the infected population. Enzyme immunoassays (EIA) verified with a direct fluorescence antigen test were evaluated and compared with culture controls. Reactive samples detected using EIA were regarded as being true positive if they were also positive according to the verification test. The sensitivity of the verified EIA test was 91%, the specificity 100%., the positive predictive valued 100%, and the negative predictive value 99%. The sensitivity of the culture was 90%. Low age is the most predictable risk factor for genital Chlamydia trachomatis infection. Compared with cultures. EIA verified with a direct fluorescence antigen test is a rapid and effective method for clinical use.