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Evaluation of patients' experiences with antidepressants reported by means of a medicine reporting system.
van Geffen, E C G; van der Wal, S W; van Hulten, R; de Groot, M C H; Egberts, A C G; Heerdink, E R.
Afiliação
  • van Geffen EC; Science Shop for Medicines, Department of Pharmaceutical Sciences, Utrecht University, The Netherlands.
Eur J Clin Pharmacol ; 63(12): 1193-9, 2007 Dec.
Article em En | MEDLINE | ID: mdl-17874086
OBJECTIVE: To assess experiences related to antidepressant use reported to an internet-based medicine reporting system and to compare the nature of the side effects reported by patients with those reported by health care professionals (HCPs). METHODS: All reports submitted from May 2004 to May 2005 to an internet-based medicine reporting system in The Netherlands related to the use of antidepressants were analysed. Spontaneous reports of adverse drug reactions on antidepressants from HCPs received by The Netherlands Pharmacovigilance Centre Lareb from May 2004 to May 2005 were included for comparison. RESULTS: Of the 2232 individuals who submitted a report to the internet-based medicine reporting system, 258 submitted a report on antidepressants. Of these, 92 individuals (36%) reported on effectiveness, 40 (16%) of whom reported on ineffectiveness, and 217 (84%) submitted a report on side effects, with 202 (78%) reporting a total of 630 side effects that were experienced as negative. Fourteen individuals (5%) reported a practical issue and four (2%) reported a reimbursement issue. Of all 630 side effects reported, 48% resulted in the patient discontinuing the antidepressant therapy; of these 29% did not inform their HCP. Of all the side effects reported, 52% were perceived as "very negative". In comparison to the side effects reported by HCPs, patients more often reported apathy, excessive sweating, ineffectiveness, somnolence, insomnia, sexual problems and weight increase. CONCLUSION: Patients report the ineffectiveness and side effects of antidepressant therapy as negative and leading to discontinuation of the therapy. Patients and HCPs differ in the nature of the reported side effects. Patient experiences should be included in the evaluation of antidepressant treatment in clinical practice.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Notificação de Reações Adversas a Medicamentos / Internet / Antidepressivos Tipo de estudo: Evaluation_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Eur J Clin Pharmacol Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Holanda País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Notificação de Reações Adversas a Medicamentos / Internet / Antidepressivos Tipo de estudo: Evaluation_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Eur J Clin Pharmacol Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Holanda País de publicação: Alemanha