Circulating RANKL/OPG in polymyalgia rheumatica.
Clin Exp Rheumatol
; 25(4): 621-3, 2007.
Article
em En
| MEDLINE
| ID: mdl-17888221
ABSTRACT
OBJECTIVE:
To evaluate whether RANKL/OPG balance is modified in PMR patients, either in the active phase of the disease or during corticosteroid treatment.METHODS:
Circulating levels of RANKL and OPG were assayed by enzyme-linked immunosorbent assay in PMR patients with active untreated disease and in patients treated by corticosteroids over a 12-month follow-up period.RESULTS:
We found no statistically significant differences in circulating levels of OPG between PMR patients either in the active phase of the disease or during all follow-up period compared to normal controls. On the other hand, systemic production of sRANKL is increased and is not modulated by corticosteroid treatment.CONCLUSION:
In PMR increased levels of sRANKL may be related to bone osteoporosis. Further investigations are necessary to evaluate the relationship between the RANK/RANKL/OPG system and bone turnover in PMR patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimialgia Reumática
/
Ligante RANK
/
Osteoprotegerina
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Clin Exp Rheumatol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália