Energetics of quadruplex-drug recognition in anticancer therapy.
Curr Cancer Drug Targets
; 7(6): 520-40, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17896919
ABSTRACT
Immortality of tumour cells is strictly correlated to telomerase activity. Telomerase is overexpressed in about 85% of tumour cells and maintains telomere length contributing to cell immortalisation, whereas in somatic cells telomeres progressively shorten until cell death occurs by apoptosis. Different drugs can promote telomeric G-rich overhangs which fold into quadruplex structures that inhibit telomerase activity. Detailed studies on drug-quadruplex complexes are essential to understand quadruplex recognition and address drug design. This review will discuss the energetic aspects of quadruplex-drug interactions with a particular attention to physico-chemical methodologies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Telomerase
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Curr Cancer Drug Targets
Assunto da revista:
ANTINEOPLASICOS
/
NEOPLASIAS
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália