Significance of an epidermal growth factor receptor mutation in cerebrospinal fluid for carcinomatous meningitis.
Intern Med
; 46(19): 1651-5, 2007.
Article
em En
| MEDLINE
| ID: mdl-17917328
ABSTRACT
We report a case of epidermal growth factor receptor (EGFR) inhibitor-sensitive lung adenocarcinoma with carcinomatous meningitis who showed a good response to gefitinib, an oral tyrosine kinase inhibitor of EGFR. This good response to gefitinib treatment was attributed to evidence of an EGFR mutation, L858R in exon 21, which was detected in a small amount of cerebrospinal fluid (CSF) before the positive CSF cytology. Patients with carcinomatous meningitis often have a poor performance status, and therefore diagnostic approaches and therapeutic methods are also often limited. Detection of EGFR mutations may be a useful method for non-small cell lung cancer diagnosis, and also facilitate determination of appropriate therapeutic protocols.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA de Neoplasias
/
Receptores ErbB
/
Meningite
/
Mutação
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Guideline
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Intern Med
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
2007
Tipo de documento:
Article