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Cytotoxic lignans from the stem bark of Magnolia officinalis.
Youn, Ui-Joung; Chen, Quan Cheng; Jin, Wen-Yi; Lee, Ik-Soo; Kim, Hong-Jin; Lee, Jong-Pill; Chang, Min-Jung; Min, Byung-Sun; Bae, Ki-Hwan.
Afiliação
  • Youn UJ; College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
J Nat Prod ; 70(10): 1687-9, 2007 Oct.
Article em En | MEDLINE | ID: mdl-17918910
ABSTRACT
Three new lignans, 4'-methoxymagndialdehyde ( 1), 4'-methoxymagnaldehyde B ( 2), and 4'-methoxymagnaldehyde E ( 3), were isolated from hexane- and EtOAc-soluble fractions of the stem bark of Magnolia officinalis, together with eight known compounds ( 4- 11). The structures of compounds 1- 3 were determined on the basis of spectroscopic and physicochemical data analysis. Compounds 1- 11 were tested in vitro for their cytotoxic activity against the K562, HeLa, and A549 cancer cell lines. Among the compounds tested, compound 1 showed the most potent cytotoxic activity against these cancer cell lines, with IC50 values of 3.9, 1.5, and 3.7 microg/mL, respectively.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Lignanas / Magnolia / Antineoplásicos Fitogênicos Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Nat Prod Ano de publicação: 2007 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Lignanas / Magnolia / Antineoplásicos Fitogênicos Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Nat Prod Ano de publicação: 2007 Tipo de documento: Article