Collagen-hydroxyapatite composite enhances regeneration of calvaria bone defects in young rats but postpones the regeneration of calvaria bone in aged rats.

ABSTRACT

The potential differences in bone repair of calvaria defects treated with a collagen sponge (HELISTAT) or a collagen-hydroxyapatite composite (HEALOS) in young and aged rats were evaluated at 8 weeks after surgery. A histomorphometric analysis of new bone formation and an evaluation of angiogenesis, mast cell, and eosinophil local infiltration were performed. Evaluation showed that HELISTAT induced a similar amount of new bone in both young and aged rats. However this occurred to a lesser degree than in young rats treated with HEALOS. The largest number of blood vessels was present in the defects of aged rats treated with HEALOS, and the number of mast cells was highest in the defects treated with HELISTAT in both young and aged rats. Eosinophils were present to the greatest extent in defects treated with HEALOS in comparison to defects treated with HELISTAT in both young and aged rats. Collagen-hydroxyapatite composite (HEALOS) enhances calvarial bone repair more than collagen sponge alone (HELISTAT) in young rats but not in aged rats at 8 weeks after surgery. HEALOS appears to induce a more intense inflammatory response than HELISTAT especially in aged rats.