In vitro transformation of dithiopyr by rat liver enzymes: conversion of methylthioesters to acids by oxygenases.
Xenobiotica
; 21(10): 1265-71, 1991 Oct.
Article
em En
| MEDLINE
| ID: mdl-1796604
ABSTRACT
1. Transformation of dithiopyr by rat liver enzymes in vitro produced the corresponding monoacids as the predominant metabolites. 2. Transformations of the methylthioester functional groups in dithiopyr to the monoacids were mediated via rat liver microsomal oxygenases, and not via esterases. 3. Based on the formation of a dithiopyr-glutathione conjugate, the mechanism of monoacid formation is believed to proceed through an initial sulphur oxidation of the methylthioester group and a subsequent nucleophilic displacement reaction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
Limite:
Animals
Idioma:
En
Revista:
Xenobiotica
Ano de publicação:
1991
Tipo de documento:
Article