[Adequacy of new systemic antifungal agents prescriptions in a teaching hospital]. / Revue de pertinence des prescriptions des nouveaux antifongiques systémiques dans un hôpital universitaire.
Med Mal Infect
; 37 Suppl 3: S223-8, 2007 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-17977680
ABSTRACT
OBJECTIVES:
The aim of this study was to evaluate the adequacy and the conformity of prescriptions of new systemic antifungal drugs to guidelines and scientific data. PATIENTS ANDMETHODS:
Each prescription of liposomal amphotericin B (lip Amb), voriconazole, and caspofungin made between May 2003 and May 2004 in a teaching hospital were reviewed by an infectious diseases specialist. He used criteria based on marketing authorization, national recommendations, and scientific data.RESULTS:
One hundred and fifteen files were studied during the 12-month period and 203 prescriptions analyzed. Most patients were immunodepressed. The indication of the treatment was appropriate for 127 prescriptions (62.6%). Dose and drug interactions were compliant with prescription rules for 158 prescriptions (77.8%). Among the causes of misuse, 16.3% concerned combinations of antifungals. Prescriptions of liposomal amphotericin B, voriconazole and caspofungin complied with guidelines respectively in 69.7, 60.6 and 36.8% of the cases. Among the 127 appropriate prescriptions, the use of cheaper molecules with an equivalent clinical effectiveness would have allowed saving 13.6% of the total cost of these prescriptions.CONCLUSIONS:
This study will lead us to implement policies for new antifungal prescription.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fidelidade a Diretrizes
/
Antifúngicos
Tipo de estudo:
Guideline
/
Observational_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
Fr
Revista:
Med Mal Infect
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
França