Refinement of a transplantation project in the non-human primate by the use of a humane endpoint.
Lab Anim
; 41(4): 456-69, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17988440
ABSTRACT
An assessment scheme was developed to establish a humane endpoint in a pig-to-primate renal xenotransplantation project, with a view to minimizing and controlling any pain or suffering conditions in the animals involved while still achieving the scientific objective. In particular, the assessment criteria for identifying the earliest endpoint are described, bearing in mind both the researcher's need to obtain top-quality data and the ethical need to safeguard the animals. The scheme should also be applicable to other experiments involving non-human primates (e.g. allotransplantation, survival after major surgery, pharmacological safety tests) because it considers reproducible general parameters together with aspects specific to each experimental model.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cuidados Pós-Operatórios
/
Suínos
/
Transplante Heterólogo
/
Bem-Estar do Animal
/
Transplante de Rim
/
Modelos Animais
/
Macaca fascicularis
Tipo de estudo:
Prognostic_studies
Aspecto:
Ethics
Limite:
Animals
Idioma:
En
Revista:
Lab Anim
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália