Treatment of POEMS syndrome with bevacizumab.
Haematologica
; 92(10): 1438-9, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-18024383
ABSTRACT
We report a case of POEMS syndrome which relapsed six years after autologous peripheral blood stem cell transplantation. According to encouraging data published recently, we treated the patient with cyclophosphamide, dexamethasone and the VEGF-antibody bevacizumab. After an initial improvement, the subsequent course was complicated by severe adverse events leading to multiorgan failure and death. This dramatic decline highlights the need for further investigation before using bevacizumab in patients with POEMS syndrome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome POEMS
/
Anticorpos Monoclonais
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Haematologica
Ano de publicação:
2007
Tipo de documento:
Article