Improving the sensitivity limit of surface plasmon resonance biosensors by detecting mixed interference signals.
Appl Opt
; 46(33): 8068-73, 2007 Nov 20.
Article
em En
| MEDLINE
| ID: mdl-18026545
ABSTRACT
We demonstrate that the sensitivity limit of intensity-based surface plasmon resonance (SPR) biosensors can be enhanced when we combine the effects of the phase and amplitude contributions instead of detecting the amplitude variation only. Experimental results indicate that an enhancement factor of as much as 20 times is achievable, yet with no compromise in measurement dynamic range. While existing SPR biosensor systems are predominantly based on the angular scheme, which relies on detecting intensity variations associated with amplitude changes only, the proposed scheme may serve as a direct system upgrade approach for these systems. The new measurement scheme may therefore lead to a strong impact in the design of SPR biosensors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Refratometria
/
Algoritmos
/
Processamento de Sinais Assistido por Computador
/
Técnicas Biossensoriais
/
Ressonância de Plasmônio de Superfície
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Idioma:
En
Revista:
Appl Opt
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
China