Stachybotrydial selectively enhances fibrin binding and activation of Glu-plasminogen.
J Antibiot (Tokyo)
; 60(11): 674-81, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-18057696
ABSTRACT
Stachybotrydial, a triprenyl phenol metabolite from a fungus, has a plasminogen modulator activity selective to Glu-plasminogen. Stachybotrydial enhanced fibrin binding and activation of Glu-plasminogen (2- to 4-fold enhancement at 60-120 microM) but not of Lys-plasminogen. Approximately 1.2-1.6 moles of [3H]stachybotrydial bound to Glu-plasminogen to exert such effects. The selective modulation of the Glu-plasminogen function by stachybotrydial may be related to alteration of its conformational status.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasminogênio
/
Compostos de Espiro
/
Benzofuranos
/
Fibrina
/
Ativadores de Plasminogênio
Limite:
Humans
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão