Your browser doesn't support javascript.
loading
Neurologic complications of liver transplantation in pediatric patients with the hepatic form of Wilson's disease.
Erol, Ilknur; Alehan, Füsun; Ozcay, Figen; Canan, Oguz; Haberal, Mehmet.
Afiliação
  • Erol I; Baskent University Faculty of Medicine, Department of Pediatrics, Pediatric Neurology Division, 6. Cadde 72/3 Bahcelievler, Ankara, Turkey. ilknur_erol@yahoo.com
J Child Neurol ; 23(3): 293-300, 2008 Mar.
Article em En | MEDLINE | ID: mdl-18079318
The literature contains very little documentation on neurologic complications in liver transplant recipients for Wilson's disease. We retrospectively reviewed 17 consecutive cases of pediatric liver transplantation for the hepatic form of Wilson's disease to assess the types of neurologic complications that occurred, the incidence of those problems, and associated factors in this patient group. The patients were 12 boys and 5 girls; indications for liver transplantation were fulminant hepatic failure in 3 patients and chronic hepatic failure in 14 patients. Neurologic complications were observed in 10 of the 17 patients as 16 episodes. The most common neurologic complications were seizure (7 episodes in 6 patients) and sudden-onset headache (5 episodes in 4 patients). Tacrolimus was identified as the only possible cause of headache in 3 episodes. Encephalitis was the cause in 1 and intracranial hemorrhage was the cause in the other headache episode. We also noted 1 episode of tremor, 1 episode of acute dystonic reaction, 1 episode of diffuse encephalopathy, and 1 episode of common peroneal nerve palsy. Immunosuppressive agents were the primary cause of 12 of the 16 episodes of neurologic complications. Uremia with hypertension, compression of the right common peroneal nerve, encephalitis, and intracranial hemorrhages attributable to coagulopathy caused 1 neurologic episode each. Neurologic complications in patients with the hepatic form of Wilson's disease were frequent during the first 30 days after pediatric liver transplantation but did not affect survival. Transplantation teams should be aware of the high incidence of neurologic complications in pediatric patients with the hepatic form of Wilson's disease.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Transplante de Fígado / Cefaleia / Degeneração Hepatolenticular / Imunossupressores Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Child Neurol Assunto da revista: NEUROLOGIA / PEDIATRIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Turquia País de publicação: Estados Unidos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Transplante de Fígado / Cefaleia / Degeneração Hepatolenticular / Imunossupressores Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Child Neurol Assunto da revista: NEUROLOGIA / PEDIATRIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Turquia País de publicação: Estados Unidos