Induction of mediator release from human glomerular mesangial cells by the terminal complement components C5b-9.
Int Arch Allergy Appl Immunol
; 96(4): 331-7, 1991.
Article
em En
| MEDLINE
| ID: mdl-1809690
ABSTRACT
Exposure of cultured human glomerular mesangial cells (GMC) to normal human serum and an activator of the complement system results in rapid uptake of the terminal complement proteins C5b-9 by the cells. This 'innocent bystander' complement attack, however, does not result in cell killing, but in the stimulation of the GMC to release prostaglandin E (PGE), interleukin 1 (Il-1) and tumor necrosis factor (TNF). Endogenously synthesized Il-1 in turn activates PGE release, indicating that the C5b-9 attack initiates an autocrine feedback stimulation. Together with the fact that C5b-9 is found in many forms of glomerulonephritis, the data point to a role of the terminal complement proteins in the initiation and perpetuation of an inflammatory response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prostaglandinas E
/
Complexo de Ataque à Membrana do Sistema Complemento
/
Interleucina-1
/
Fator de Necrose Tumoral alfa
/
Mesângio Glomerular
Limite:
Humans
Idioma:
En
Revista:
Int Arch Allergy Appl Immunol
Ano de publicação:
1991
Tipo de documento:
Article