Direct enantiomeric separation of terfenadine and its major acid metabolite by high-performance liquid chromatography, and the lack of stereoselective terfenadine enantiomer biotransformation in man.
J Chromatogr
; 571(1-2): 291-7, 1991 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-1810960
ABSTRACT
Direct enantiomeric separation of terfenadine and its major acid metabolite was achieved by using two different chiral stationary phase columns with two different mobile phase systems. Further, the enantiomeric composition of the human urinary acid metabolite has been determined, indicating a non-stereoselective biotransformation in man.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatografia Líquida de Alta Pressão
/
Terfenadina
Limite:
Humans
/
Male
Idioma:
En
Revista:
J Chromatogr
Ano de publicação:
1991
Tipo de documento:
Article