A Brønsted acid mediated cascade enone synthesis from aldehydes containing a tethered propargylsilane.
J Org Chem
; 73(4): 1631-4, 2008 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-18197686
ABSTRACT
MeSO3H effects the intramolecular allenylation of a series of aldehydes 1 to provide allenyl alcohol product 3 as a single diastereoisomer. Cyclization proceeds rapidly at -78 degrees C. However, when the reaction is performed at room temperature, aldehyde 1 provides enone product 7 instead. A mechanism for the formation of this product is proposed in which the initially formed allenyl alcohol 3 undergoes dehydration to provide an allyl carbocation, which is trapped with water, thereby installing the enone.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos
/
Aldeídos
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Reino Unido