In vitro biosynthesis of [Thr2, Leu5, D-Hiv8, Leu10]cyclosporin, a cyclosporin-related immunosuppressive peptolide.
Biomed Biochim Acta
; 50(10-11): S260-3, 1991.
Article
em En
| MEDLINE
| ID: mdl-1820056
ABSTRACT
We were able to prepare an enzyme fraction from crude extracts of the mycelium of the fungus Cylindrotrichum Bonorden, which is capable of synthesizing the new peptolide SDZ 214-103 under consumption of the constitutive amino acids, D-2-hydroxyisovaleric acid, ATP and S-adenosyl-L-methionine. The enzyme does not synthesize CyA, while cyclosporin synthetase does not synthesize the peptolide. Peptolide synthetase has a high molecular weight in the same range as cyclosporin synthetase (about 1.5 MDa).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclosporinas
Idioma:
En
Revista:
Biomed Biochim Acta
Ano de publicação:
1991
Tipo de documento:
Article