Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.
Bioorg Med Chem Lett
; 18(4): 1346-9, 2008 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-18207394
ABSTRACT
Derivatives of milnacipran were synthesized and studied as monoamine transporter inhibitors. Potent analogs were discovered at NET (9k) and at both NET and SERT (9s and 9u). A pharmacophore model was established based on the conformational analysis of milnacipran in aqueous solution using NMR techniques and was consistent with the SAR results.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclopropanos
/
Proteínas Vesiculares de Transporte de Monoamina
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos