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Cervicovaginal evaluation in macaques used as a model for topical microbicide safety studies.
Scorpio, Diana G; Ruben, Dawn S; Liao, Zhaohao; Hildreth, James E; Fletcher, Craig A.
Afiliação
  • Scorpio DG; Department of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA. dscorpio@jhmi.edu
J Med Primatol ; 37 Suppl 1: 65-73, 2008 Feb.
Article em En | MEDLINE | ID: mdl-18269532
INTRODUCTION: Macaques are a commonly used non-human primate (NHP) model to evaluate safety and efficacy of topically applied vaginal microbicides. Cervicovaginal evaluation for topical microbicide safety studies requires proper technique, equipment, supplies, and sequence of sample collection. MATERIALS AND METHODS: Eleven rhesus macaques received a comprehensive sequential cervicovaginal examination under sedation before treatment and 24 hours post-instillation of test material. Examination was initiated with colposcopy, followed by diagnostics including vaginal culture, pH determination, cervicovaginal lavage, and cervicovaginal biopsy. RESULTS: Overall, the methods performed yielded samples that were appropriate for diagnostic evaluation and interpretation, and the macaques experienced minimal discomfort and complications. DISCUSSION: This paper provides a descriptive summary of compiled techniques required to conduct a safety evaluation for topically applied vaginal microbicides. This novel method-based approach should be methodically executed when evaluating a vaginally-applied, topical microbicide candidate.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vagina / Colo do Útero / Modelos Animais / Macaca mulatta / Anti-Infecciosos Limite: Animals Idioma: En Revista: J Med Primatol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Dinamarca

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vagina / Colo do Útero / Modelos Animais / Macaca mulatta / Anti-Infecciosos Limite: Animals Idioma: En Revista: J Med Primatol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Dinamarca