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Basiliximab induction therapy for live donor kidney transplantation: a long-term follow-up of prospective randomized controlled study.
Clin Exp Nephrol ; 12(5): 376-381, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-18327678
ABSTRACT

BACKGROUND/AIMS:

The effect of basiliximab induction therapy on long-term patient and graft survival is not yet clear. We aimed to evaluate if there is any advantage of routine basiliximab induction on the long-term outcome of living related donor kidney transplantation.

METHODS:

One hundred adult recipients with their first kidney allograft were randomized into two treatment groups, one group received basiliximab and the second served as a control. All patients received a maintenance triple immunosuppressive therapy (steroids, cyclosporine (CsA) micro-emulsion and azathioprine) and were followed up thoroughly for 7 years.

RESULTS:

Basiliximab significantly reduced the proportion of patients who experienced acute rejection in the first year (18/50) when compared to the control group (31/50), and in 7 years (28/50) when compared to (37/50) in controls. The cumulative steroid dose used throughout the whole study period was significantly lower in the basiliximab group. The overall incidence of post-transplant complications was comparable among the two treatment groups. There was no significant difference in patient or graft survival; 7 years patient and graft survival were 92, 76% for basiliximab and 92, 80% for the control group, respectively.

CONCLUSION:

Routine basiliximab induction significantly reduced the incidence of acute rejection without any noticeble beneficial effect on the long-term renal transplantation outcome.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Transplante de Rim / Doadores Vivos / Rejeição de Enxerto / Imunossupressores / Anticorpos Monoclonais Tipo de estudo: Primary_study Aspecto clínico: Prognóstico / Terapia Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin Exp Nephrol Assunto da revista: Nefrologia Ano de publicação: 2008 Tipo de documento: Artigo País de afiliação: Egito