Follow-up on infants treated with porcine surfactant replacement for severe neonatal and infant respiratory distress syndrome: antigenic reactivity evaluation.
Drugs Exp Clin Res
; 17(10-11): 511-5, 1991.
Article
em En
| MEDLINE
| ID: mdl-1841041
ABSTRACT
A follow-up was carried out on twenty-two children (thirteen of whom were newborn) who had been treated with porcine surfactant (Curosurf) for respiratory distress syndrome. All the infants were enrolled in the follow-up at different times after surfactant replacement to evaluate the clinical status and the incidence (if any) of respiratory disease, adverse drug effects and allergic conditions. Twelve of the twenty-two children treated completed the follow-up. Seven prematurely-born children died of endocranial haemorrhage; two children died of malignant development of the basal pathology (leukaemia). Treatment with pig surfactant appears to cause no allergic side effects. Skin and laboratory tests performed were negative.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Síndrome do Desconforto Respiratório do Recém-Nascido
/
Produtos Biológicos
/
Surfactantes Pulmonares
/
Hipersensibilidade a Drogas
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Drugs Exp Clin Res
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Itália