Formation of cyclosporins by Tolypocladium inflatum.
Folia Microbiol (Praha)
; 36(6): 549-56, 1991.
Article
em En
| MEDLINE
| ID: mdl-1841870
ABSTRACT
Submerged cultures of the low-production strain of Tolypocladium inflatum DSM 63544 formed a mixture of cyclosporins (CS) consisting of CS-A, CS-B, "CS-3" and "CS-4". Glucose, sucrose and maltose were highly favored for biomass production but provided a different physiological state necessary for CS biosynthesis. Not only the magnitude of CS production but also the proportion of individual components of the CS mixture were affected by the C source. Intensive CS synthesis was in correlation with the formation of CS-3. Lower yields of CS were accompanied by an increased proportion of CS-A in the CS complex. The best specific production of CS was achieved on the glucose medium, the highest yield of CS-A on the maltose medium. There was no remarkable relationship between the biomass formation and the intensity of CS synthesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclosporinas
/
Fungos Mitospóricos
Idioma:
En
Revista:
Folia Microbiol (Praha)
Ano de publicação:
1991
Tipo de documento:
Article