DL-alpha-difluoromethylornithine (DFMO)-Berenil combination: therapeutic and prophylactic activity against Trypanosoma brucei brucei infection in mice.
Rev Elev Med Vet Pays Trop
; 44(4): 443-5, 1991.
Article
em En
| MEDLINE
| ID: mdl-1843826
ABSTRACT
The therapeutic and prophylactic activity of difluoromethylornithine (DFMO) (2% in drinking water for 4 days) and Berenil (7 mg/kg live weight intraperitoneally) combination was investigated in mice infected with Trypanosoma brucei brucei. Using a previously described mouse model of the African trypanosomosis of the central nervous system, it was demonstrated that the combination was curative and acted synergistically. However, if used prophylactically it had no advantage over Berenil alone.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tripanossomicidas
/
Trypanosoma brucei brucei
/
Tripanossomíase Africana
/
Eflornitina
/
Diminazena
Limite:
Animals
Idioma:
En
Revista:
Rev Elev Med Vet Pays Trop
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Nigéria