Molecular identification of two genotypes of mumps virus causing two regional outbreaks in Asturias, Spain.
J Clin Virol
; 42(4): 425-8, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18440271
ABSTRACT
BACKGROUND:
In spite of universal vaccination, several sporadic cases of mumps infection, which could produce outbreaks, are detected every year in different countries.OBJECTIVE:
Mumps virus strains causing two regional outbreaks in Asturias (Spain) were phylogenetically characterized. STUDYDESIGN:
Mumps virus strains, which were detected in samples from patients belonging to two regional outbreaks in Asturias, were characterized by sequencing of the SH gene and further alignment to homologous sequences of representative strains of the different mumps genotypes.RESULTS:
Two different strains (Ast/SP02 and Ast/SP07) were isolated. Sequence analysis revealed that while Ast/SP02 belonged to genotype H, Ast/SP07 was phylogenetically close to UK02-19, a reference strain for a new genotype. Both strains belonged to different genotypes from those used in the vaccination (Jeryl-Lynn strain is genotype A).CONCLUSION:
Mumps virus strains different from those used in vaccination program can cause mumps outbreaks even in vaccinated patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Surtos de Doenças
/
Caxumba
/
Vírus da Caxumba
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Humans
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Clin Virol
Assunto da revista:
VIROLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Espanha